Development, Characterization and In vitro Evaluation of Solid Dispersion Formulations of Low Aqueous Soluble BCS Class II Drug Pitavastatin with Poloxamer 407 and HPMC

This study was aimed to boost up the dissolution rate of a sparingly aqueous soluble BCS Class II drug pitavastatin (PTV) by solid dispersion (SD) techniques using two hydrophilic polymers poloxamer 407 and hydroxypropylmethylcellulose (HPMC). Low solubility PTV is associated with less oral bioavailability, real challenge in preparing appropriate dosage form. To enhance solubility, physical mixing SD formulations were developed fusion solvent evaporation methods polymers, HPMC. Scanning electron microscopy (SEM) investigation indicated that molecules homogeneously dispersed carrier prepared different formulation at 1:2 1:3 ratios PTV: polymer assuming amorphous state. The thermogravimetric profiles demonstrated stable 198°C began decompose rapidly significant weight loss as temperature raised over 190°C. Formulations high temperature. In vitro studies illustrated cumulative release HPMC/poloxamer mixing, better compared pure powder (61.42±0.91%). Among all approaches, displayed higher releases than formulations. results current clearly (1:2) (S3, S1) method possess enhanced profile (96.06%; 95.62%) (F3; 94.62%, F1; 87.05%). Whereas (P2; 82.32%, P4; 80.28%) containing amount (ratio 1:3) exhibited superior rates (P3; 68.70%, P1; 71.52%) having quantity 1:2) 407. It apparent from findings this S1, F3, F1) very promising approach for improving PTV. Moreover, ratio approaches found more effective upgrade Dhaka Univ. J. Pharm. Sci. 20(3): 325-336, 2022 (June) Centennial Special Issue